Simone Vagnozzi is an Italian former professional tennis player.
Vagnozzi had a career high ATP singles ranking of world No. 161 achieved on 7 November 2011. He also had a career high ATP doubles ranking of world No. 74 achieved on 4 April 2011.
Vagnozzi made his ATP Tour singles debut at the 2004 Grand Prix Hassan II on clay courts in Casablanca, Morocco when he successfully advanced through three qualifying rounds to reach his first career main draw. In qualifying he defeated Talal Ouahabi, followed by leading Thomas Shimada 6–0, 2–0 when he had to retire from the match, and finally Björn Rehnquist to gain a main draw birth. In the first round he would go on extend his winning streak to four matches by defeating Jean-René Lisnard in straight sets but would ultimately fall in the second round to Swiss player Ivo Heuberger. He made his ATP Tour doubles debut at the 2005 Croatia Open where he received a direct entry alongside Slovenian player Ladislav Švarc. They were defeated in the first round by an 18-year-old Novak Djokovic and Janko Tipsarević.
Vagnozzi reached 24 singles finals in his career, posting a record of 8 wins and 16 losses which includes a 1–3 record in ATP Challenger finals. Additionally, he reached 54 doubles finals across his career with a record of 28 wins and 26 losses which includes a 16–21 record in ATP Challenger finals. He reached 1 career doubles final on the ATP Tour at the 2010 Swedish Open alongside compatriot Andreas Seppi. They were defeated by Robert Lindstedt and Horia Tecău in straight sets.
Vagnozzi, alongside Darren Cahill, is currently the coach of fellow Italian ATP player Jannik Sinner.